ABSTRACT
<p><b>AIM</b>To find a new PDT sensitizer.</p><p><b>METHODS</b>There were four complexes (Cu, Zn, Co, Ni) synthesized through reaction of metal and deprivating-Mg bacteriochlorophyll in the organic solvent. Their antitumor action was detected by MTT.</p><p><b>RESULTS</b>The ultraviolet-visual spectrum and the fluorescence spectrum of these complexes showed that synthesis of these four complexes was succeeded. And these metal complexes have potent antitumor action on two kinds of leukaemic cells.</p><p><b>CONCLUSION</b>Metal bacteriochlorophylls as PDT sensitizers have very good properties and this is a way to develop new PDT sensitizers.</p>
Subject(s)
Humans , Antineoplastic Agents , Chemistry , Pharmacology , Bacteriochlorophylls , Chemistry , Cell Proliferation , Cobalt , Chemistry , Copper , Chemistry , HL-60 Cells , Cell Biology , K562 Cells , Cell Biology , Metals, Heavy , Chemistry , Nickel , Chemistry , Organometallic Compounds , Chemistry , Pharmacology , Photosensitizing Agents , Chemistry , Pharmacology , Zinc , ChemistryABSTRACT
<p><b>AIM</b>Understanding the modes and activities of metal bacterial chlorophylls as PHD sensitizers with DNA.</p><p><b>METHODS</b>The modes and activities of the interaction of DNA and metal complexes of bacterial chlorophyll, which have been prepared by extraction and synthesis reaction, have been discussed according to the ultraviolet-visual spectrum and nucleic acid electrophoresis.</p><p><b>RESULTS</b>It indicates that the system of DNA and metal complexes have enchanced the interaction by the ultraviolet-visual spectrum. At the same time, it also indicates that metal complexes of bacterial chlorophyll and DNA have different combining way and have strong cutting effect in illumination by the nucleic acid electrophoresis.</p><p><b>CONCLUSION</b>This paper proved that metal bacterial chlorophylls as PHD sensitizers have great advantage.</p>